A recent review article written by Epinex’s staff and published by Springer-Nature Journal “Inflammation Research’ 2017, highlights the utility of GA measurement both as mediator of inflammation as well as a marker to track hyperglycemia and other diabetic complications. This review shows an association of glycated albumin with inflammation and other diabetic complication like atherosclerosis, diabetic retinopathy, nephropathy (CKD) and rheumatoid arthritis.
The review outlined the following specific associations between glycated albumin and inflammatory disease processes:
GA has a role in atherosclerosis. GA causes inflammation of endothelial cells lining the blood vessels, which can lead to development of plaque in arterial walls and further leads to Coronary Artery Disease (CAD).
GA is also involved diabetic retionopathy. It causes release of inflammatory molecules like cytokines in retinal cells that lead to diabetic retinopathy.
GA causes chronic kidney disease/nephropathy. Increased GA is associated with irregular renal nephrin (nephrin is a protein necessary for the proper functioning of the renal filtration barrier), promoting proteinuria (presence of excess proteins in the urine) and glomeruloscelrosis (hardening of the glomerulus in the kidney) and eventually nephropathy (thickening of glomerular basement membrane) / chronic kidney disease (CKD).
GA is also involved in rheumatoid arthritis (inflammation of joints) and studies have shown that GA was able to predict the progress of rheumatoid factor +RA.
A rapid test for GA could be a significant benefit for patients to monitor inflammation and other related complications on a monthly basis. Epinex has patented a rapid test for Glycated Albumin (G1A) and is developing this test for clinical trials. G1A tests measures total albumin and glycated albumin exclusively (not fructosamine), in a hand held device as a POCT (Point of Care Test) for doctors’ offices and clinics, and as an OTC (Over The Counter) test for general public use.
Source: Glycated albumin (GA) and inflammation: role of GA as a potential marker of inflammation. Roohk, H.V., Zaidi, A.R., Patel, D. Inflamm. Res. (2017).