"Glycated albumin is a potential diagnostic tool for diabetes mellitus" - Yang, et al.
December 13, 2012
About this study:
Using a community-based population cross-sectional study, this study investigated the validity of an enzymatic method for glycated albumin (GA) measurements and evaluated its utility as a diagnostic tool for diabetes mellitus (DM).
In total, 1,211 participants from the city of Harbin, People’s Republic of China, were enrolled in the study. A receiver operating characteristic (ROC) analysis for GA, fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) measurements in diagnosed and undiagnosed DM were compared, based on a definition of DM using 1999 WHO criteria.
The researchers also estimated the correlation among GA, HbA1c and other clinical characteristics. Significant and positive correlations of fasting serum GA with FPG (r 0.8097) and HbA1c (r 0.8976) were found in participants enrolled in the study. ROC analysis for GA predicting undiagnosed DM with a cut-off point of 15.7% was similar to that of FPG and HbA1c. Therefore, the data indicates that GA is a potential tool for DM diagnosis.