EPINEX DIABETES BLOG

The American Association for Clinical Chemistry (AACC) and the American Diabetes Association (ADA) have recognized the need to look beyond HbA1c for biomarkers in diabetes management. They have joined forces and holding a symposium during the 69th AACC Annual Scientific Meeting & Clinical Lab Expo taking place in San Diego July 30-August 3 2017. Symposium will explore supplemental biomarkers “Looking Beyond HbA1c ”. it will be held during AACC meeting on August 1, 2017 at 2:

A recent review article in Critical Reviews in Clinical Laboratory Sciences analyzes glycemic control indicators such as hemoglobin A1c (HbA1c), glycated albumin (GA), and GA/HbA1c ratio. This article concludes that it is important to be able to select an appropriate glycated protein depending on each patient’s health status. Reports indicate that HbA1c is not always a suitable glycemic indicator even though it “is one of the most important diagnostic factors for diabetes” Co

The Journal of the American Medical Association recently published an article that analyzed the effectiveness of hemoglobin A1c (HbA1c) as a measure of diabetes outcomes. Lead researchers Dr. Kasia Lipska, MD and Dr. Harlan Krumholz, MD concluded that “treatment should be selected to target specific complications and inherent risks, not solely glucose levels.” Therefore, the authors suggest an alternative view that recommends identifying drugs for diabetes care based on outco

Clinical Chemistry and Laboratory Medicine (CCLM) recently published an analysis of hemoglobin A1c (HbA1c) and glycated albumin (GA) as effective glycemic markers. This study, led by Dr. Roberto Testa, MD of INRCA-IRCCS National Institute concluded that GA% (GA on total albumin ratio) is a useful indicator for diabetes management and monitoring where HbA1c is limited. As summarized in the article, several past studies support the potential for GA to be an overall marker for d

Diabetes Monitoring and Diagnosis Beyond A1c

Dr. Yehuda Handelsman of the Metabolic Institute of America recently discussed the limitations of HbA1c as a glycemic indicator. He concluded that HbA1c “is not the most accurate measure for patients with severe kidney disease, sickle cell anemia, [and] various blood diseases.” Although continuous glucose monitoring (CGM) is also a suggested measure of diabetes outcomes, Dr. Handelsman points out that CGM is not available for many type 2 diabetics. Therefore, he proposed meas

"Objectives: We report a case of a patient with diabetes mellitus and unexpectedly low hemoglobin A1c results associated with paroxysmal nocturnal hemoglobinuria (PNH). We review the impact of shortened RBC half-life on the interpretation of hemoglobin A1c levels. However, elevated serum glucose (random), fructosamine, and glycated albumin suggest ongoing hyperglycemia." Click here to read the full article Source- http://www.empr.com/medical-news/hba1c-misleading-in-diabetic-

"The glycated albumin (GA) to HbA1c ratio (GA/HbA1c ratio) has been reported to reflect postprandial hyperglycemia. Carbohydrate is the primary dietary macronutrient that causes postprandial hyperglycemia. Thus, we investigated whether carbohydrate intake was associated with the GA/HbA1c ratio in patients with type 2 diabetes." Click here to read the full article Source- http://www.scirp.org/journal/PaperInformation.aspx?PaperID=63296 #Diabetes #Glycatedalbumin #DiabetesBlog

"GA levels may be a better indicator of glycemic control than HbA1c and pre-dialysis glucose levels, especially as a means of evaluating the glucose excursions in diabetic HD patients." Click here to read the full article Source- http://rrtjournal.biomedcentral.com/articles/10.1186/s41100-016-0013-7 http://www.epinex.com/#!glycated-albumin/yrxvx http://www.epinexdiabetesblog.com/#!Glycated-Albumin-The-Next-A1c/cjds/563a6a670cf28330832d23be #GlycatedAlbumin #glycatedhemoglobin

"OBJECTIVE- Slowing the diabetes epidemic in Africa requires improved detection of prediabetes. A1C, a form of glycated hemoglobin A, is recommended for diagnosing prediabetes. The glycated proteins, fructosamine and glycated albumin (GA), are hemoglobin-independent alternatives to A1C, but their efficacy in Africans is unknown. Our goals were to determine the ability of A1C, fructosamine, and GA to detect prediabetes in U.S.-based Africans and the value of combining A1C wit